Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development

Microtubules that assemble the mitotic spindle are generated by centrosomal nucleation, chromatin-mediated and nucleation from surface of other microtubules mediated augmin complex. Impairment in apical progenitors developing mouse brain induces p53-dependent apoptosis causes non-lethal microcephaly. Whether disruption non-centrosomal has similar effects is unclear. Here, we show, using embryos, conditional knockout subunit Haus6 led to defects delay. This triggered massive abortion development. Co-deletion Trp53 rescued cell death, but surviving failed organize a pseudostratified epithelium, development still failed. could be explained exacerbated errors resulting chromosomal including increased DNA damage. Thus, contrast centrosomes, crucial for progenitor mitosis, and, even absence p53, progression